Inflammatory bowel diseases (IBD), that include Crohn's disease and ulcerative colitis, - are long lasting diseases, progressing under the influence of a wide range of factors: genetic and environmental. For the moment, there come up more and more monogenic forms of IBD, in which one defected gene changes the whole clinical pattern. The monogenic forms of IBD manifest usually very early, in the childhood. A major part of these types of diseases deal with primary immunodeficiency. Primary immune deficiency diseases (PIDD) - are a group of genetic diseases, caused by the defects of the genes, responsible for immunologic response. Allogenic transplantation of hematopoietic stem cells (AHSCT) is a treatment option for a large amount of PIDD and for the treatment of complications. The review of PIDD that usually cause inflammation in the bowel, will be presented the results of treatment of this group of diseases with allogenic HSCT will be demonstrated.