before the treatment

ELIGIBILITY CRITERIA

(AHSCT)
Inclusion Criteria
        Acceptable criteria for treatment:

        • Age 16 – 70 years old
        • Absence of severe chronic infections
        • Negative serology HBV, HCV, HIV
        • Absence of mental and cognitive deficits and ability to provide informed consent
        • Absence of gross cognitive disturbances
        • Absence of severe concomitant diseases

        Systemic autoimmune diseases:


        • Diagnosed Multiple Sclerosis with EDSS between 1.5 and 6.5 (documented progression/relapses over the previous year, with or without gadolinium-enhancing lesions).
        • Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
        • Severe systemic vasculitis
        • Systemic lupus erythematosus
        • Systemic sclerosis
        • Crohn's disease
        • Other severe systemic autoimmune conditions, including connective tissue diseases

        Adequate organ function:


        • Cardiac LV Ejection Fraction >45%
        • Total Lung capacity > 60%
        • Pulmonary artery pressure < 45 mmHg
        • DLCO/VA>50%
                        Exclusion Criteria

                        List of contraindications for treatment
                        :

                        • A positive test for HIV, Hepatitis B and Hepatitis C.
                        • Severe extensive or prolonged infection caused by viruses, fungi and bacteria.
                        • Uncontrolled diabetes.
                        • Evidence myelodysplasia or other non-autoimmune cytopenia.
                        • Having received a cytotoxic agent within one month prior to AHSCT.
                        • Pregnancy or at risk of pregnancy, including those unwilling to practice active contraception during the time of therapy.
                        • Psychiatric illness, mental deficiency, or gross cognitive dysfunction.
                        • Inability to give written and informed consent in accordance with world ethics guidelines for medical treatment.
                        • High disability level of MS patient

                        Any condition, obstructing the normal functioning of the main organs

                        (Heart, Kidneys, Lung, Liver etc.)
                        - As this would limit your ability to receive high-dose immunosuppressive therapy
                        with Autologous Hematopoietic Stem Cell Transplantation.